Products for Research Use Only
RegisterLogin

Lidocaine (GMP)

CAT: 0804-HY-B0185GSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0185GSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Lidocaine (GMP) is Lidocaine produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].
CAS Number
137-58-6
Product Name Alternative
Lignocaine (GMP)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; ERK; MEK; NF-κB; Sodium Channel
Type
GMP Small Molecules
Related Pathways
Apoptosis; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lidocaine-gmp.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(C)C=CC=C1C)CN(CC)CC
Molecular Formula
C14H22N2O
Molecular Weight
234.34
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582 (Pt 1) :11.|[2]Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19 (1) :233.|[3]Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin Pharmacol Toxicol. 2013 Jul;113 (1) :31-6.|[4]Kadota S, et al. Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets. Eur Heart J. 2013 Apr;34 (15) :1147-56.|[5]Potet F, et al. GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Mol Pharmacol. 2020 Nov;98 (5) :540-547. |[6]Wang F, et al. In Vitro Drug Screening Using iPSC-Derived Cardiomyocytes of a Long QT-Syndrome Patient Carrying KCNQ1 & TRPM4 Dual Mutation: An Experimental Personalized Treatment. Cells. 2022 Aug 11;11 (16) :2495.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B0185-01Lidocaine
HY-B0185S2Lidocaine-d6
HY-B0185A-01Lidocaine (hydrochloride)
HY-101361Lidocaine methiodide
HY-B0185S1-01Lidocaine-d10
HY-B0185R-01Lidocaine (Standard)
HY-B0185AS1Lidocaine-d6 (hydrochloride)
HY-Z6540Lidocaine impurity 20
HY-Z6535-01Lidocaine impurity 12
HY-44009-01Lidocaine impurity 1

Alternative Products

CatalogName
A1450-5Lidocaine

Popular Products