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Lidocaine-d10

CAT: 0804-HY-B0185S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0185S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].
CAS Number
851528-09-1
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; ERK; MEK; NF-κB; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Stem Cell/Wnt
Field of Research
Cancer; Cardiovascular Disease
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
[2H]C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])[2H])CC(NC1=C(C=CC=C1C)C)=O
Molecular Formula
C14H12D10N2O
Molecular Weight
244.40
Precautions
H302
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin Pharmacol Toxicol. 2013 Jul;113 (1) :31-6.|[3]Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582 (Pt 1) :11.|[4]Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19 (1) :233.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
AR-L01644-01Lidocaine-d10
CS-O-06723Lidocaine-d10 Hydrochloride
TMID-0262-01Lidocaine-d10 (N, N-diethyl-d10)
TRC-L397806-1MGLidocaine-d10 (N,N-diethyl-d10)
sc-489175Lidocaine-d10 N-Oxide
L2180-05Lidocaine-d10 Hydrochloride (2- (Diethyl-d10-amino) -N- (2,6-dimethylphenyl) acetamide Hydrochloride, Basicaina-d10, Batixim-d10, Dynexan-d10, Heweneural-d10, Licain-d10)
MBS6117550-01Lidocaine-d10 Hydrochloride (2-(Diethyl-d10-amino)-N-(2,6-dimethylphenyl)acetamide Hydrochloride, Basicaina-d10, Batixim-d10, Dynexan-d10, Heweneural-d10, Licain-d10)
TRC-KIT8672-1X1MLLidocaine-d10 Hydrochloride (1.0 mg/mL in Methanol)
A1450-5Lidocaine

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