Lidocaine (hydrochloride)

• UNSPSC Description:

  Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2].

• Target Antigen:

  Apoptosis; ERK; MEK; NF-κB; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;MAPK/ERK Pathway;Membrane Transporter/Ion Channel;NF-κB;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Lidocaine-hydrochloride.html

• Purity:

  99.96

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL

• Smiles:

  O=C(NC1=C(C)C=CC=C1C)CN(CC)CC.[H]Cl

• Molecular Weight:

  270.80

• References & Citations:

  [1]Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582(Pt 1):11.|[2]Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19(1):233.|[3]Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin Pharmacol Toxicol. 2013 Jul;113(1):31-6.Eur Spine J. 2022 Sep 24.|J Phys D Appl Phys. 2019 Aug; 52(46).|Cell Rep Methods. 2023 Oct 23;3(10):100599.|Dig Dis Sci. 2021 Jan 12.|Drug Des Devel Ther. 2024 Apr 9:18:1103-1114.|Int Immunopharmacol. 2023 Jan 11;115:109706.|J Neuroinflammation. 2017 Nov 2;14(1):211.|Mol Med Rep. 2022 May;25(5):150.|Nat Methods. 2021 Jul;18(7):788-798.|Neurogastroenterol Motil. 2023 Sep 21;e14677.|PLoS Pathog. 2023 Feb 3;19(2):e1011126.|Stem Cell Res Ther. 2021 Feb 4;12(1):107.|University of Glasgow. School of Cancer Sciences.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  Launched

• CAS Number:

  73-78-9