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Lidocaine

CAT: 0804-HY-B0185-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0185-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].
CAS Number
137-58-6
Product Name Alternative
Lignocaine
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; ERK; MEK; NF-κB; Sodium Channel
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Lidocaine.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 5 mg/mL
Smiles
O=C(NC1=C(C)C=CC=C1C)CN(CC)CC
Molecular Formula
C14H22N2O
Molecular Weight
234.34
Precautions
H302
References & Citations
[1]Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582 (Pt 1) :11.|[2]Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19 (1) :233.|[3]Li Z, et al. Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats. Basic Clin Pharmacol Toxicol. 2013 Jul;113 (1) :31-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
ERK; MEK; NF-κB
Citation 01
Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Dig Dis Sci. 2021 Dec;66 (12) :4384-4397.|Drug Des Devel Ther. 2024 Apr 9:18:1103-1114.|Int Immunopharmacol. 2023 Feb:115:109706.|J Ethnopharmacol. 2025 Apr 14:347:119803.|J Neuroinflammation. 2017 Nov 2;14 (1) :211.|Mol Med Rep. 2022 May;25 (5) :150.|Nat Methods. 2021 Jul;18 (7) :788-798.|Neurogastroenterol Motil. 2023 Nov;35 (11) :e14677.|PLoS One. 2025 Nov 4;20 (11) :e0335932.|PLoS Pathog. 2023 Feb 3;19 (2) :e1011126.|Reprod Toxicol. 2025 May:134:108895.|Stem Cell Res Ther. 2021 Feb 4;12 (1) :107.|Transl Psychiatry. 2025 May 17;15 (1) :172.|University of Glasgow. School of Cancer Sciences.|Biomater Adv. 2025 Aug 15:178:214452.|Eur Spine J. 2022 Nov;31 (11) :2960-2971.|J Phys D Appl Phys. 2019 Aug; 52 (46) .

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