Eletriptan-d5

Eletriptan-d5

• CAS Number: 1126745-65-0
• UNSPSC Description: Eletriptan-d5 is the deuterium labeled Eletriptan[1]. Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[2].
• Target Antigen: 5-HT Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Inflammation/Immunology
• Solubility: 10 mM in DMSO
• Smiles: O=S(CCC1=CC=C2C(C(C([2H])([2H])[C@@H]3N(CCC3)C([2H])([2H])[2H])=CN2)=C1)(C4=CC=CC=C4)=O
• Molecular Weight: 387.55
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66(8):1129-49.|[3]Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug358(2):212-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported