Eletriptan-d5

CAT: 0804-HY-A0039S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0039S1Size:1 mg
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Description
Eletriptan-d5 is the deuterium labeled Eletriptan[1]. Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[2].
CAS Number
[1126745-65-0]
UNSPSC
12352005
Target
5-HT Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=S(CCC1=CC=C2C(C(C([2H])([2H])[C@@H]3N(CCC3)C([2H])([2H])[2H])=CN2)=C1)(C4=CC=CC=C4)=O
Molecular Formula
C22H21D5N2O2S
Molecular Weight
387.55
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66 (8) :1129-49.|[3]Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044) : a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug358 (2) :212-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor

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