Eletriptan (hydrobromide) (Standard)

CAT: 0804-HY-A0010R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0010R-01Size:5 mg
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Description
Eletriptan hydrobromide (Standard) is an analytical standard for Eletriptan hydrobromide. This product is intended for research and analytical applications. Eletriptan hydrobromide (Eletriptan HBr) is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, with Ki of 0.92 nM and 3.14 nM, respectively[1][2][3][4][5][6].
CAS Number
[177834-92-3]
Product Name Alternative
Eletriptan HBr (Standard) ; UK-116044 (hydrobromide) (Standard)
UNSPSC
12352005
Target
5-HT Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eletriptan-hydrobromide-standard.html
Smiles
O=S(CCC1=CC2=C(NC=C2C[C@@H]3N(CCC3)C)C=C1)(C4=CC=CC=C4)=O.Br
Molecular Formula
C22H27BrN2O2S
Molecular Weight
463.43
References & Citations
[1]Napier C, et al. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol, 1999, 368 (2-3), 259-268.|[2]MaassenVanDenBrink A, et al. Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels. Neurology, 2000, 55 (10), 1524-1530.|[3]Gupta P, et al. The in vivo pharmacological profile of eletriptan (UK-116,044) : a potent and novel 5-HT (1B/1D) receptor agonist. Eur J Pharmacol, 2000, 398 (1), 73-81.|[4]Hoskin KL, et al. The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat. Brain Res, 2004, 998 (1), 91-99.|[5]Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044) : a new 5-HT1B/1D receptor agonist with anti-migraine activity[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1998, 358: 212-219.|[6]Johnson D E, et al. Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain[J]. European journal of pharmacology, 2001, 425 (3) : 203-210.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
5-HT1 Receptor

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Alternative Products

CatalogName
M12677-01Eletriptan hydrobromide
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A11418-50Eletriptan hydrobromide 50mg
A11418-500Eletriptan hydrobromide 500mg
A11418-2Eletriptan hydrobromide 2mg
A11418-10Eletriptan hydrobromide 10mg
A11418-100Eletriptan hydrobromide 100mg
A11418-5Eletriptan hydrobromide 5mg
A11418-200Eletriptan hydrobromide 200mg
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