Products for Research Use Only
RegisterLogin

Ritonavir-13C, d3

CAT: 0804-HY-90001S1Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-90001S1Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ritonavir-13C, d3 is the 13C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
Product Name Alternative
ABT 538-13C, d3; RTV-13C, d3
UNSPSC
12352005
Target
Apoptosis; HIV; HIV Protease; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
CC(C)[C@H](NC(N([13C]([2H])([2H])[2H])CC1=CSC(C(C)C)=N1)=O)C(N[C@H](C[C@H](O)[C@@H](NC(OCC2=CN=CS2)=O)CC3=CC=CC=C3)CC4=CC=CC=C4)=O
Molecular Formula
C36 13CH45D3N6O5S2
Molecular Weight
724.96
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6 (1) :212.|[3]Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277 (1) :423-31.|[4]Eagling VA, et al. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol. 1997 Aug;44 (2) :190-4.|[5]Drewe J, et al. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochem Pharmacol. 1999 May 15;57 (10) :1147-52.|[6]Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2 (5) :261-9.|[7]Kumar GN, et al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug;27 (8) :902-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-17410S2Iloperidone-13C, d3
HY-15463S3Imatinib-13C, d3
HY-10158S1Bosutinib-13C, d3
HY-10121S4-01Asenapine-d3,13C
HY-B0002BS2Ondansetron-13C, d3
HY-15651SAlvelestat-13C, d3
HY-113432S2Nudifloramide-13C, d3
HY-106827S1Trimegestone-13C, d3
HY-10219S1-01Rapamycin-13C, d3
HY-143848STadalafil-13C, d3

Alternative Products

CatalogName
TMIJ-0076-01Ritonavir-13C-d3
A8203-5.1Ritonavir

Popular Products