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Asenapine-13C, d3

CAT: 0804-HY-10121S2Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10121S2Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Asenapine-13C, d3 is 13C and deuterated labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder[1][2].
CAS Number
2747915-30-4
Product Name Alternative
Org 5222-13C, d3
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C2C(CN(C2)[13C]([2H])([2H])[2H])C3=C4C=CC=C3)=C(O4)C=C1.O=C(O)/C=C\C(O)=O
Molecular Formula
C20 13CH17D3ClNO5
Molecular Weight
405.85
References & Citations
[1]M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23 (1) :65-73.|[2]Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl) . 2008 Feb;196 (3) :417-29.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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