Asenapine-13C,d3

Asenapine-13C,d3

• CAS Number: 2747915-30-4
• UNSPSC Description: Asenapine-13C,d3 is 13C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder[1][2].
• Target Antigen: 5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology; Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC(C2C(CN(C2)[13C]([2H])([2H])[2H])C3=C4C=CC=C3)=C(O4)C=C1.O=C(O)/C=C\C(O)=O
• Molecular Weight: 405.85
• References & Citations: [1]M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73.|[2]Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported