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Azelastine-13C, d3

CAT: 0804-HY-B0462ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0462ASSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azelastine-13C, d3 is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].
UNSPSC
12352005
Target
Histamine Receptor; Isotope-Labeled Compounds; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Endocrinology; Metabolic Disease; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=C1N(C2CCN([13C]([2H])([2H])[2H])CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4
Molecular Formula
C21 13CH21D3ClN3O
Molecular Weight
385.91
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Carlos D. Zappia, et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7 (6) : e00531.|[3]Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1 (2) :191-201.|[4]Li Yang, et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin. 2020 Oct 28 : 1-7.|[5]Mohamed M Elseweidy, et al. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8.|[6]Shao-Cheng Liu, et al. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. Eur Arch Otorhinolaryngol. 2017 Feb;274 (2) :845-853.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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