Troglitazone-d4

• Description :

  Troglitazone-d4 is deuterium labeled Troglitazone. Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.

• Product Name Alternative :

  CS-045-d4

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Apoptosis; Autophagy; Ferroptosis; Isotope-Labeled Compounds; PPAR

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  98.19

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1SC(CC2=C([2H])C([2H])=C(C([2H])=C2[2H])OCC3(C)OC4=C(CC3)C(C)=C(O)C(C)=C4C)C(N1)=O

• Molecular Formula :

  C24H23D4NO5S

• Molecular Weight :

  445.56

• Precautions :

  H302

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fujita M, et al. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J Exp Clin Cancer Res. 2017 Jul 3;36 (1) :91.|[3]Nazim UM, et al. PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. Oncotarget. 2017 Apr 18;8 (16) :26819-26831.|[4]Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43 (4) :527-50.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [2749370-85-0]