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Troglitazone (Standard)

CAT: 0804-HY-50935R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50935R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Troglitazone (Standard) is the analytical standard of Troglitazone. This product is intended for research and analytical applications. Troglitazone is an orally active PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes.
CAS Number
97322-87-7
Product Name Alternative
CS-045 (Standard)
UNSPSC
12352005
Target
Apoptosis; Autophagy; Ferroptosis; PPAR; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/troglitazone-standard.html
Smiles
O=C(SC1CC(C=C2)=CC=C2OCC3(C)OC(C(CC3)=C4C)=C(C)C(C)=C4O)NC1=O
Molecular Formula
C24H27NO5S
Molecular Weight
441.54
References & Citations
[1]Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43 (4) :527-50.|[2]Fujita M, et al. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J Exp Clin Cancer Res. 2017 Jul 3;36 (1) :91.|[3]Nazim UM, et al. PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. Oncotarget. 2017 Apr 18;8 (16) :26819-26831.|[4]Knowler WC, et al. Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Diabetes. 2005 Apr;54 (4) :1150-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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