Diethyl butylmalonate-D9

• Description :

  Diethyl butylmalonate-d9 is the deuterium labeled Diethyl butylmalonate (HY-44178) . Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log (IGC50-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease[1][2].

• UNSPSC :

  12352211

• Target :

  Isotope-Labeled Compounds; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology; Neurological Disease

• Purity :

  98

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OCC)C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C(OCC)=O

• Molecular Formula :

  C11H11D9O4

• Molecular Weight :

  225.33

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]T I Netzeva, et al. Partial least squares modelling of the acute toxicity of aliphatic compounds to Tetrahymena pyriformis. SAR QSAR Environ Res. 2003 Aug;14 (4) :265-83.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1189865-34-6]