Diethyl butylmalonate-D9

CAT: 0804-HY-44178S-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-44178S-01Size:5 mg
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Description
Diethyl butylmalonate-d9 is the deuterium labeled Diethyl butylmalonate (HY-44178) . Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log (IGC50-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease[1][2].
CAS Number
[1189865-34-6]
UNSPSC
12352211
Target
Isotope-Labeled Compounds; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Purity
98
Solubility
10 mM in DMSO
Smiles
O=C(OCC)C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C(OCC)=O
Molecular Formula
C11H11D9O4
Molecular Weight
225.33
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]T I Netzeva, et al. Partial least squares modelling of the acute toxicity of aliphatic compounds to Tetrahymena pyriformis. SAR QSAR Environ Res. 2003 Aug;14 (4) :265-83.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
D443882Diethyl 2-n-Butylmalonate-d9
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sc-234672Diethyl tert-butylmalonate
sc-278958Diethyl sec-butylmalonate
D21410-01Diethyl N-butylmalonate
D21413-01Diethyl sec-butylmalonate 96%
TRC-D443880-10GDiethyl 2-n-Butylmalonate
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sc-218196Diethyl 2- (n-Butyl-d9) malonate
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