Tebuconazole-d9

• Description :

  Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.

• CAS Number :

  [1246818-83-6]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H361-H411

• Target :

  Cytochrome P450; Fungal

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research :

  Infection

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(CCC1=CC=C(Cl)C=C1)CN2C=NC=N2

• Molecular Formula :

  C16H13D9ClN3O

• Molecular Weight :

  316.87

• Precautions :

  P264-P270-P273-P280-P330-P391-P405-P501

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Warrilow AG, et al. Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother. 2013 Mar;57 (3) :1352-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported