Saquinavir-d9

CAT: 0804-HY-17007SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17007SSize:1 mg
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Description
Saquinavir-d9 (Ro 31-8959-d9) is the deuterium labeled Saquinavir (HY-17007) . Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells[1][2].
CAS Number
[1356355-11-7]
Product Name Alternative
Ro 31-8959-d9
UNSPSC
12352005
Target
Apoptosis; Calcium Channel; HIV; HIV Protease; Interleukin Related; Isotope-Labeled Compounds; JNK; NO Synthase; p38 MAPK; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
C([C@H]([C@H](CC1=CC=CC=C1)NC([C@@H](NC(=O)C2=NC3=C(C=C2)C=CC=C3)CC(N)=O)=O)O)N4[C@H](C(NC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C[C@]5([C@@](C4)(CCCC5)[H])[H]
Molecular Formula
C38H41D9N6O5
Molecular Weight
679.90
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Pettoello-Mantovani M, et al. Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: an in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues. Antimicrob Agents Chemother. 1997 Sep;41 (9) :1880-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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