BR351 precursor

• Description:

  BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1].

• UNSPSC:

  12352005

• Target:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BR351_precursor.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)[C@@H](N(S(=O)(C1=CC=C(OCCOS(=O)(C2=CC=C(C)C=C2)=O)C=C1)=O)CC3=CC=CC=C3)C(NO)=O

• Molecular Formula:

  C27H32N2O8S2

• Molecular Weight:

  576.68

• References & Citations:

  [1]Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2 (R) -[[ (4-methoxyphenyl) sulfonyl] (benzyl) - and (3-picolyl) -amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50 (23) :5752-64.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [960113-89-7]