BR351 precursor

CAT: 0804-HY-43586Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-43586Size:1 Each
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Description
BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1].
CAS Number
[960113-89-7]
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BR351_precursor.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@@H](N(S(=O)(C1=CC=C(OCCOS(=O)(C2=CC=C(C)C=C2)=O)C=C1)=O)CC3=CC=CC=C3)C(NO)=O
Molecular Formula
C27H32N2O8S2
Molecular Weight
576.68
References & Citations
[1]Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2 (R) -[[ (4-methoxyphenyl) sulfonyl] (benzyl) - and (3-picolyl) -amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50 (23) :5752-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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