BR351

• Description :

  BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1].

• UNSPSC :

  12352005

• Target :

  MMP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/BR351.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)[C@@H](N(S(=O)(C1=CC=C(OCCF)C=C1)=O)CC2=CC=CC=C2)C(NO)=O

• Molecular Formula :

  C20H25FN2O5S

• Molecular Weight :

  424.49

• References & Citations :

  [1]Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2 (R) -[[ (4-methoxyphenyl) sulfonyl] (benzyl) - and (3-picolyl) -amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50 (23) :5752-64.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-13; MMP-2; MMP-8; MMP-9

• CAS Number :

  [960113-85-3]