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ERK2-IN-3

CAT: 0804-HY-18849Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18849Size:1 Each
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Description
ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2WT and Erk2DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively[1].
CAS Number
1415050-57-5
UNSPSC
12352005
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erk2-in-3.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(NC(C2=CC=CC(C(F)(F)F)=C2)=O)C=C1C3=CC=C4C(C=NC(NC5CC5)=N4)=C3
Molecular Formula
C26H21F3N4O
Molecular Weight
462.47
References & Citations
[1]Hari SB, et al. Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases. Chem Biol. 2014;21 (5) :628-635.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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