ERK2-IN-3

• Description :

  ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2WT and Erk2DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively[1].

• UNSPSC :

  12352005

• Target :

  ERK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/erk2-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=CC=C(NC(C2=CC=CC(C(F)(F)F)=C2)=O)C=C1C3=CC=C4C(C=NC(NC5CC5)=N4)=C3

• Molecular Formula :

  C26H21F3N4O

• Molecular Weight :

  462.47

• References & Citations :

  [1]Hari SB, et al. Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases. Chem Biol. 2014;21 (5) :628-635.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1415050-57-5]