ERK2-IN-3

ERK2-IN-3

• CAS Number: 1415050-57-5
• UNSPSC Description: ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2WT and Erk2DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively[1].
• Target Antigen: ERK
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/erk2-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=C(NC(C2=CC=CC(C(F)(F)F)=C2)=O)C=C1C3=CC=C4C(C=NC(NC5CC5)=N4)=C3
• Molecular Weight: 462.47
• References & Citations: [1]Hari SB, et al. Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases. Chem Biol. 2014;21(5):628-635.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported