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Elubrixin (hydrochloride)

CAT: 0804-HY-18263Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18263Size:1 Each
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Description
Elubrixin (SB-656933) hydrochloride is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin hydrochloride inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM) . Elubrixin hydrochloride has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation[1][2][3].
CAS Number
688763-65-7
Product Name Alternative
SB-656933 (hydrochloride)
UNSPSC
12352005
Target
CXCR; Interleukin Related
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/elubrixin-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C(S(=O)(N2CCNCC2)=O)=C1O)Cl)NC3=C(Cl)C(F)=CC=C3.Cl
Molecular Formula
C17H18Cl3FN4O4S
Molecular Weight
499.77
References & Citations
[1]Mozaffari S, et al. Inflammatory bowel disease therapies discontinued between 2009 and 2014. Expert Opin Investig Drugs. 2015;24 (7) :949-56.|[2]Lazaar AL, et al. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol. 2011 Aug;72 (2) :282-93.|[3]Nicholson GC, et al. A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther. 2007;20 (1) :52-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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