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JNJ 17029259

CAT: 0804-HY-18185Size: 1 EachDry Ice: NoHazardous: No
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Description
JNJ 17029259 is an orally active and selective VEGF-R2 kinase inhibitor. JNJ 17029259 inhibits VEGF-mediated signal transduction. JNJ 17029259 has anti-angiogenic activity[1][2].
CAS Number
314267-57-7
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jnj-17029259.html
Solubility
10 mM in DMSO
Smiles
CC(C)(N)C(C=C1)=CC=C1C2=NC(NC3=CC=C(CCN4CCOCC4)C=C3)=NC=C2C#N
Molecular Formula
C26H30N6O
Molecular Weight
442.56
References & Citations
[1]Mohammed S. I. Makki, et al. Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors. Journal of Chemistry. 2014. Article ID 430573.|[2]Reuman M, et al. Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasound-mediated addition of MeLi-CeCl3 to a nitrile. J Org Chem. 2008 Feb 1;73 (3) :1121-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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