Abacavir-d4

• Description :

  Abacavir-d4 is the deuterium labeled Abacavir. Abacavir is a potent nucleoside analog reverse-transcriptase inhibitor (NRTI) [1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Apoptosis; HIV; Isotope-Labeled Compounds; Reverse Transcriptase

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Apoptosis; Others

• Field of Research :

  Infection

• Solubility :

  10 mM in DMSO

• Smiles :

  OC[C@@H]1C=C[C@H](N2C=NC3=C(NC4C([2H])([2H])C4([2H])[2H])N=C(N)N=C23)C1

• Molecular Formula :

  C14H14D4N6O

• Molecular Weight :

  290.36

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Charneira C, et al. Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity. Chem Res Toxicol. 2011 Dec 19;24 (12) :2129-41.|[3]Hervey PS, et al. Abacavir: a review of its clinical potential in patients with HIV infection. Drugs. 2000 Aug;60 (2) :447-79.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1260619-56-4]