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Abacavir-d4

CAT: 0804-HY-17423SSize: 1 mgDry Ice: NoHazardous: No
CAT#: HY-17423SSize: 1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abacavir-d4 is the deuterium labeled Abacavir. Abacavir is a potent nucleoside analog reverse-transcriptase inhibitor (NRTI) [1][2].
CAS Number
[1260619-56-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; HIV; Isotope-Labeled Compounds; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1C=C[C@H](N2C=NC3=C(NC4C([2H])([2H])C4([2H])[2H])N=C(N)N=C23)C1
Molecular Formula
C14H14D4N6O
Molecular Weight
290.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Charneira C, et al. Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity. Chem Res Toxicol. 2011 Dec 19;24 (12) :2129-41.|[3]Hervey PS, et al. Abacavir: a review of its clinical potential in patients with HIV infection. Drugs. 2000 Aug;60 (2) :447-79.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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MBS6094437-01Abacavir-d4
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