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Abacavir

CAT: 0804-HY-17423-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17423-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].
CAS Number
136470-78-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HIV; Reverse Transcriptase; Telomerase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Abacavir.html
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)
Smiles
NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1
Molecular Formula
C14H18N6O
Molecular Weight
286.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5 (12) :e14221.|[2]Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218 (2) :228-233. |[3]Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23 (7) :3815. |[4]McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19 (1) :15-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
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