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Abacavir (Standard)

CAT: 0804-HY-17423R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17423R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].
CAS Number
136470-78-5
UNSPSC
12352005
Target
Apoptosis; HIV; Reference Standards; Reverse Transcriptase; Telomerase
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/abacavir-standard.html
Smiles
NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1
Molecular Formula
C14H18N6O
Molecular Weight
286.33
References & Citations
[1]Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5 (12) :e14221.|[2]Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218 (2) :228-233. |[3]Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23 (7) :3815. |[4]McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19 (1) :15-23.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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