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Abacavir (monosulfate)

CAT: 0804-HY-17423B-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17423B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].
CAS Number
216699-07-9
UNSPSC
12352005
Hazard Statement
H317-H319-H341-H351-H361
Target
Apoptosis; HIV; Reverse Transcriptase; Telomerase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/abacavir-monosulfate.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.O=S(O)(O)=O
Molecular Formula
C14H20N6O5S
Molecular Weight
384.41
Precautions
P261-P264-P272-P280-P302+P352-P305+P351+P338-P362+P364-P405-P501
References & Citations
[1]Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5 (12) :e14221.|[2]Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218 (2) :228-233. |[3]Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23 (7) :3815. |[4]McComsey GA, et al. Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS. 2005 Jan 3;19 (1) :15-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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