Ifosfamide-d4

• Description :

  Ifosfamide-d4 is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  DNA Alkylator/Crosslinker; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Cell Cycle/DNA Damage; Others

• Field of Research :

  Cancer

• Purity :

  99.85

• Solubility :

  10 mM in DMSO

• Smiles :

  ClCCN1P(NCCCl)(OCC([2H])([2H])C1([2H])[2H])=O

• Molecular Formula :

  C7H11D4Cl2N2O2P

• Molecular Weight :

  265.11

• Precautions :

  H301

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91 (5) :357-68.|[3]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8 (3) :220-30.|[4]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232 (1) :182-92.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1189701-13-0]