Ifosfamide-d4

• Description:

  Ifosfamide-d4 is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  DNA Alkylator/Crosslinker; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage; Others

• Field of Research:

  Cancer

• Purity:

  99.85

• Solubility:

  10 mM in DMSO

• Smiles:

  ClCCN1P(NCCCl)(OCC([2H])([2H])C1([2H])[2H])=O

• Molecular Formula:

  C7H11D4Cl2N2O2P

• Molecular Weight:

  265.11

• Precautions:

  H301

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91 (5) :357-68.|[3]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8 (3) :220-30.|[4]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232 (1) :182-92.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1189701-13-0