Ifosfamide

• Description:

  Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H319, H340, H350, H360

• Target:

  DNA Alkylator/Crosslinker

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ifosfamide.html

• Purity:

  99.89

• Solubility:

  DMSO : 125 mg/mL

• Smiles:

  ClCCN1P(OCCC1)(NCCCl)=O

• Molecular Formula:

  C7H15Cl2N2O2P

• Molecular Weight:

  261.09

• Precautions:

  H301, H319, H340, H350, H360

• References & Citations:

  [1]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91 (5) :357-68.|[2]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8 (3) :220-30.|[3]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232 (1) :182-92.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  3778-73-2