Ifosfamide

• Description :

  Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H319, H340, H350, H360

• Target :

  DNA Alkylator/Crosslinker

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ifosfamide.html

• Purity :

  99.89

• Solubility :

  DMSO : 125 mg/mL

• Smiles :

  ClCCN1P(OCCC1)(NCCCl)=O

• Molecular Formula :

  C7H15Cl2N2O2P

• Molecular Weight :

  261.09

• Precautions :

  H301, H319, H340, H350, H360

• References & Citations :

  [1]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91 (5) :357-68.|[2]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8 (3) :220-30.|[3]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232 (1) :182-92.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [3778-73-2]