Sonidegib (Standard)

• Description:

  Sonidegib (Standard) is the analytical standard of Sonidegib. This product is intended for research and analytical applications. Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].

• UNSPSC:

  12352100

• Target:

  Reference Standards; Smo

• Related Pathways:

  Others; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  O=C (C1=C (C) C (C (C=C2) =CC=C2OC (F) (F) F) =CC=C1) NC3=CC=C (N=C3) N4C[C@@H] (C) O[C@@H] (C) C4

• Molecular Formula:

  C26H26F3N3O3

• Molecular Weight:

  485.50

• References & Citations:

  [1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1 (3) :130-4.|[2]Irvine DA, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  956697-53-3