c-ABL-IN-6

c-ABL-IN-6

• UNSPSC Description: c-ABL-IN-6 (compound A6) is a c-ABL inhibitor with IC50 value of 16.6 nM. c-ABL-IN-6 displays higher neuroprotective effects against SH-SY5Y cell death induced by MPP+ (HY-W008719). c-ABL-IN-6 can be used for the research of neurodegenerative disorder[1].
• Target Antigen: Bcr-Abl
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/c-abl-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=C(C(NC2=CC(C(F)(F)F)=CC(C3=CN(C)N=C3)=C2)=O)C=C1NC(C4=CN=C5C(C=CN5)=C4)=O
• Molecular Weight: 518.49
• References & Citations: [1]Yang Z, et al. Discovery of conformationally constrained c-Abl inhibitors with potential neuroprotective effects against Parkinson's disease. Bioorg Med Chem. 2023 Dec 15;96:117532.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported