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C-ABL-IN-6

CAT: 0804-HY-163189Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163189Size:1 Each
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Description
C-ABL-IN-6 (compound A6) is a c-ABL inhibitor with IC50 value of 16.6 nM. c-ABL-IN-6 displays higher neuroprotective effects against SH-SY5Y cell death induced by MPP+. c-ABL-IN-6 can be used for the research of neurodegenerative disorder[1].
UNSPSC
12352005
Target
Bcr-Abl
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/c-abl-in-6.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C(NC2=CC(C(F)(F)F)=CC(C3=CN(C)N=C3)=C2)=O)C=C1NC(C4=CN=C5C(C=CN5)=C4)=O
Molecular Formula
C27H21F3N6O2
Molecular Weight
518.49
References & Citations
[1]Yang Z, et al. Discovery of conformationally constrained c-Abl inhibitors with potential neuroprotective effects against Parkinson's disease. Bioorg Med Chem. 2023 Dec 15;96:117532.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl

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