AB-452

• Description :

  AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model[1].

• CAS Number :

  [2226178-35-2]

• UNSPSC :

  12352005

• Target :

  HBV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ab-452.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC([C@H]1N2C(C3=NC(OC)=C(OCCCOC)C=C3C1)=CC(C(C(O)=O)=C2)=O)C

• Molecular Formula :

  C21H26N2O6

• Molecular Weight :

  402.44

• References & Citations :

  [1]Dimitar Gotchev, et al. Structure-Activity Relationships and Discovery of (S) -6-Isopropyl-2-methoxy-3- (3-methoxypropoxy) -10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer. J. Med. Chem. January 8, 2024.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported