AB-452

• UNSPSC Description:

  AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model[1].

• Target Antigen:

  HBV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ab-452.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC([C@H]1N2C(C3=NC(OC)=C(OCCCOC)C=C3C1)=CC(C(C(O)=O)=C2)=O)C

• Molecular Weight:

  402.44

• References & Citations:

  [1]Dimitar Gotchev, et al. Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer. J. Med. Chem. January 8, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2226178-35-2