YF-452

• Description :

  YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) . YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research[1].

• UNSPSC :

  12352005

• Target :

  VEGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/yf-452.html

• Solubility :

  10 mM in DMSO

• Smiles :

  BrC1=CC=C(CN(C2=C3C=CC=C2)C4=C3CCN(C4)C(CN5CCCC5)=O)C=C1

• Molecular Formula :

  C24H26BrN3O

• Molecular Weight :

  452.39

• References & Citations :

  [1]Liu Y, et al. A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling. Sci China Life Sci. 2017 Feb;60 (2) :202-214.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  VEGFR2/KDR/Flk-1

• CAS Number :

  [1951466-83-3]