YF-452

• Description:

  YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) . YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research[1].

• UNSPSC:

  12352005

• Target:

  VEGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/yf-452.html

• Solubility:

  10 mM in DMSO

• Smiles:

  BrC1=CC=C(CN(C2=C3C=CC=C2)C4=C3CCN(C4)C(CN5CCCC5)=O)C=C1

• Molecular Formula:

  C24H26BrN3O

• Molecular Weight:

  452.39

• References & Citations:

  [1]Liu Y, et al. A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling. Sci China Life Sci. 2017 Feb;60 (2) :202-214.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  VEGFR2/KDR/Flk-1

• CAS Number:

  [1951466-83-3]