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Anti-inflammatory agent 67

CAT: 0804-HY-163116Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163116Size:1 Each
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Description
Anti-inflammatory agent 67 (compound 7a) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib , and has anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 67 has IC50s of 10.4 μM and 50 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 67 binding to different isoforms of carbonic anhydrase are 48.3 nM (CA I), 42.2 nM (CA II), 52.3 nM (CA IX), and 13.3 nM (CA XII).
CAS Number
9007-83-4
UNSPSC
12352005
Target
Carbonic Anhydrase; COX
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-67.html
Solubility
10 mM in DMSO
Smiles
O=S(OC(C=C1)=NN(C2=CC=C(S(=O)(N)=O)C=C2)C1=O)(C)=O
Molecular Formula
C11H11N3O6S2
Molecular Weight
345.35
References & Citations
[1]Badawi WA, et al. Identification of new 4- (6-oxopyridazin-1-yl) benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2201407.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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