Products for Research Use Only
RegisterLogin

Anti-inflammatory agent 68

CAT: 0804-HY-163117Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-163117Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Anti-inflammatory agent 68 (compound 7b) is a dual inhibitor of carbonic anhydrase and COX-2, a sulfonamide derivative of Polmacoxib , with anti-inflammatory properties and analgesic activity. Anti-inflammatory agent 68 has IC50s of 12.6 μM and 60 nM for COX-1 and COX-2, respectively. The Ki of anti-inflammatory agent 68 binding to different isoforms of carbonic anhydrase are 52.6 nM (CA I), 79.1 nM (CA II), 58.1 nM (CA IX), and 17.2 nM (CA XII).
CAS Number
9007-83-4
UNSPSC
12352005
Target
Carbonic Anhydrase; COX
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-68.html
Solubility
10 mM in DMSO
Smiles
O=S(OC(C=C1)=NN(C2=CC=C(S(=O)(N)=O)C=C2)C1=O)(CC)=O
Molecular Formula
C12H13N3O6S2
Molecular Weight
359.38
References & Citations
[1]Badawi WA, et al. Identification of new 4- (6-oxopyridazin-1-yl) benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2201407.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-157570-01Anti-inflammatory agent 70
HY-U00273Anti-inflammatory agent 1
HY-161815Anti-inflammatory agent 89
HY-163775Anti-inflammatory agent 88
HY-N11788Anti-inflammatory agent 43
HY-163458Anti-inflammatory agent 77
HY-162170Anti-inflammatory agent 72
HY-155997Anti-inflammatory agent 56
HY-145870Anti-inflammatory agent 13
HY-146435Anti-inflammatory agent 22

Alternative Products

CatalogName
T212447-01Anti-inflammatory agent 105
T209653-01Anti-inflammatory agent 78
T207573-01Anti-inflammatory agent 101
T60560-01Anti-inflammatory agent 15
T61302-01Anti-inflammatory agent 17
T83057-01Anti-inflammatory agent 49
T83049-01Anti-inflammatory agent 63
T83047-01Anti-inflammatory agent 65
TN9135-01Anti-inflammatory agent 98
T88958-01Anti-inflammatory agent 90

Popular Products