CTSL/CAPN1-IN-2

CTSL/CAPN1-IN-2

• CAS Number: 2410075-64-6
• UNSPSC Description: CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC50 values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry[1].
• Target Antigen: Cathepsin; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ctsl-capn1-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC2=CC=CC=C2O1)N[C@@H](CC3CCCCC3)C(N[C@H](C(C(NCC4=CC=CC=C4)=O)=O)C[C@H]5C(NCCC5)=O)=O
• Molecular Weight: 600.70
• References & Citations: [1]Xie X, et al. Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal Transduct Target Ther. 2024 Mar 6;9(1):54.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported