CTSL/CAPN1-IN-1

CTSL/CAPN1-IN-1

• UNSPSC Description: CTSL/CAPN1-IN-1 (compound 14a) is an oral active CTSL and CAPN1 inhibitor with the IC50  values of 3.34 nM and 375.1 nM for CTSL and CAPN1, respectively. CTSL/CAPN1-IN-1 shows anticoronaviral activity and anti-inflammatory effect[1].
• Target Antigen: Cathepsin
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/ctsl-capn1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC2=CC=CC=C2O1)N[C@@H](CC3=CC=C(F)C=C3)C(N[C@H](C(C(NCC4=CC=CC=C4)=O)=O)C[C@H]5C(NCCC5)=O)=O
• Molecular Weight: 612.65
• References & Citations: [1]Xie X, et al. Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal Transduct Target Ther. 2024;9(1):54. Published 2024 Mar 6.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported