TRPC antagonist 1

• Description:

  TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines[1].

• UNSPSC:

  12352005

• Target:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trpc-antagonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCN(C1=NC(C(NC2=CC=C(O)C=C2)=O)=CS1)CC3=CC=C(C=CC=C4)C4=C3

• Molecular Formula:

  C23H22N4O2S

• Molecular Weight:

  418.51

• References & Citations:

  [1]Shanshan Wang, et al. Discovery of N-alkyl-N-benzyl thiazoles as novel TRPC antagonists for the treatment of glioblastoma multiforme. European Journal of Medicinal Chemistry. 22 December 2023, 116066.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TRPC3; TRPC4; TRPC5; TRPC6; TRPC7

• CAS Number:

  3027139-12-1