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TRPC6 antagonist-1

CAT: 0804-HY-172600Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172600Size:1 Each
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Description
TRPC6 antagonist-1 (X26) is a TRPC6 antagonist with IC50 values of 0.97 μM, 3.93 μM, 5.77 μM and 4.37 μM for TRPC6, TRPC3, TRPC5 and TRPC7, respectively. TRPC6 antagonist-1 inhibits TGF-β1-induced myofibroblast differentiation, and attenuates renal fibrosis[1].
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
COC1=C2C(SC(N(C(C3=CC=C(CCCC4)C4=C3)=O)CCNC5CNCCC5)=N2)=CC=C1
Molecular Formula
C26H32N4O2S
Molecular Weight
464.62
References & Citations
[1]Ren C, et al. Benzothiazole amide analogues as antagonists of TRPC 6 channels: A therapeutic approach for kidney fibrosis. Eur J Med Chem. 2025 Jul 5;291:117628.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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