MMT3-72

• UNSPSC Description:

  MMT3-72 is a weak inhibitor of JAK1. MMT3-72 has superior efficacy and reduced p-STAT3 in DSS-induced colitis[1].

• Target Antigen:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mmt3-72.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(C1=CC=CC(NC2=NC(NC3=CC=C(OCCOC4=CC=C(/N=N/C5=CC=C(C(NCCC(O)=O)=O)C=C5)C=C4C(O)=O)C=C3)=NC=C2C)=C1)(NC(C)(C)C)=O

• Molecular Weight:

  810.87

• References & Citations:

  [1]Bu Y, et al. A gastrointestinal locally activating Janus kinase inhibitor to treat ulcerative colitis. J Biol Chem. 2023 Dec;299(12):105467.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2996158-39-3