MMT3-72

• Description :

  MMT3-72 is a weak inhibitor of JAK1. MMT3-72 has superior efficacy and reduced p-STAT3 in DSS-induced colitis[1].

• UNSPSC :

  12352005

• Target :

  JAK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mmt3-72.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C1=CC=CC(NC2=NC(NC3=CC=C(OCCOC4=CC=C(/N=N/C5=CC=C(C(NCCC(O)=O)=O)C=C5)C=C4C(O)=O)C=C3)=NC=C2C)=C1)(NC(C)(C)C)=O

• Molecular Formula :

  C40H42N8O9S

• Molecular Weight :

  810.87

• References & Citations :

  [1]Bu Y, et al. A gastrointestinal locally activating Janus kinase inhibitor to treat ulcerative colitis. J Biol Chem. 2023 Dec;299 (12) :105467.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2996158-39-3]