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NLRP3-IN-72

CAT: 0804-HY-170904Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170904Size:1 Each
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Description
NLRP3-IN-72 (Compound 2) is a benzimidazole derivative. NLRP3-IN-72 exhibits anti-inflammatory and antioxidant activities. NLRP3-IN-72 has an IC50 of 0.3 μM for NLRP3 IL-1β, a PD50 of 0.4 μM for protecting against pyroptosis, and an EC50 of 0.6 μM for inducing HO-1[1].
CAS Number
3043952-13-9
UNSPSC
12352005
Target
Heme Oxygenase (HO) ; Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
CN1C2=CC=C(F)C=C2N=C1NC3=NC(C=C(CN(C)CC)C=C4)=C4O3
Molecular Formula
C19H20FN5O
Molecular Weight
353.39
References & Citations
[1]Ryan Clark, et al. Benzimidazole derivatives. WO2024130173A1. 2024-06-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HO-1; IL-1

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