S-72

• Description :

  S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Microtubule/Tubulin; Mitosis; STAT

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/s-72.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC=C(C)C(NS(=O)(C2=CC=C(C)C=C2)=O)=C1)NCC3=CN(C)N=C3

• Molecular Formula :

  C20H22N4O3S

• Molecular Weight :

  398.48

• References & Citations :

  [1]Zhenyan Hou, et al. S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer. Pharmaceuticals (Basel) . 2023 May 15;16 (5) :749.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2446799-14-8]