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PI3Kα-IN-16

CAT: 0804-HY-161140Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161140Size:1 Each
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Description
PI3Kα-IN-16 (Z86) is a novel PI3Kα inhibitor with an IC50 value of 4.28 μM. PI3Kα-IN-16 has potent inhibitory efficiency on PI3K-mediated CRCs growth and migration. PI3Kα-IN-16 also inhibits the Wnt signaling pathway[1].
CAS Number
1448711-61-2
UNSPSC
12352005
Target
PI3K; Wnt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-16.html
Solubility
10 mM in DMSO
Smiles
CCN1C2=CC=CC=C2C3=C1C(C4=CC=CC5=C4C=CC=C5)=NC(C(OC(C)C)=O)=C3
Molecular Formula
C27H24N2O2
Molecular Weight
408.49
References & Citations
[1]Nie S, et al. β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K. Nat Prod Bioprospect. 2024 Jan 3;14 (1) :3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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