PI3Kα-IN-16

PI3Kα-IN-16

• CAS Number: 1448711-61-2
• UNSPSC Description: PI3Kα-IN-16 (Z86) is a novel PI3Kα inhibitor with an IC50 value of 4.28 μM. PI3Kα-IN-16 has potent inhibitory efficiency on PI3K-mediated CRCs growth and migration. PI3Kα-IN-16 also inhibits the Wnt signaling pathway[1].
• Target Antigen: PI3K; Wnt
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kα-in-16.html
• Solubility: 10 mM in DMSO
• Smiles: CCN1C2=CC=CC=C2C3=C1C(C4=CC=CC5=C4C=CC=C5)=NC(C(OC(C)C)=O)=C3
• Molecular Weight: 408.49
• References & Citations: [1]Nie S, et al. β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K. Nat Prod Bioprospect. 2024 Jan 3;14(1):3.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported