Lenalidomide 4'-PEG1-amine (dihydrochloride)

• UNSPSC Description:

  Lenalidomide 4'-PEG1-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG1-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lenalidomide-4-peg1-amine-dihydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC(C(CC1)N2C(C3=C(C2)C(NCCOCCN)=CC=C3)=O)=O.Cl.Cl

• Molecular Weight:

  419.30

• References & Citations:

  [1]Wang S, et al. Monofunctional intermediates for ligand-dependent target protein degradation. China, WO2017176958A1. 2017-10-12.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2624336-86-1