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IRGD peptide

CAT: 0804-HY-P0122-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0122-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
CAS Number
1392278-76-0
Product Name Alternative
C (CRGDKGPDC)
UNSPSC
12352209
Target
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iRGD_peptide.html
Purity
98.56
Solubility
H2O : ≥ 50 mg/mL
Smiles
O=C([C@@H](N)CSSC[C@H](NC1=O)C(O)=O)N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N2[C@H](C(N[C@H]1CC(O)=O)=O)CCC2)=O)=O)CCCCN)=O)CC(O)=O)=O)=O)CCCNC(N)=N
Molecular Formula
C35H57N13O14S2
Molecular Weight
948.04
References & Citations
[1]Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21 (8) :767-74.|[2]Zhang L, et al. Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells. Biomed Pharmacother. 2017 Sep;93:1136-1143.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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