DSPE-PEG2000-iRGD

• Description:

  DSPE-PEG2000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD) . iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG2000-iRGD can be used for drug delivery[1].

• UNSPSC:

  12352200

• Target:

  Integrin; Liposome

• Related Pathways:

  Cytoskeleton; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  95.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  [CRGDKGPDC (Disulfide bridge:Cys1-Cys9) ]C (CCOCCOC (NCCOP (OC[C@] (COC (CCCCCCCCCCCCCCCCC) =O) ([H]) OC (CCCCCCCCCCCCCCCCC) =O) (O) =O) =O) =O.[n]

• Molecular Weight:

  2000 (Average)

• References & Citations:

  [1]Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21 (8) :767-74.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported