Metallo-β-lactamase-IN-12

• UNSPSC Description:

  Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity[1].

• Target Antigen:

  Bacterial; Beta-lactamase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/metallo-β-lactamase-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(ONC(CCCC1=CC=CC=C1)=O)OCC2=CC=CC=C2

• Molecular Weight:

  313.35

• References & Citations:

  [1]Wu XR, et al. Discovery of hydroxamate as a promising scaffold dually inhibiting metallo- and serine-β-lactamases. Eur J Med Chem. 2023 Dec 16;265:116055.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3028594-43-3