Metallo-β-lactamase-IN-16

• UNSPSC Description:

  Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively[1].

• Target Antigen:

  Bacterial; Beta-lactamase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/metallo-β-lactamase-in-16.html

• Smiles:

  NCCS(=O)(C1=CC=C(C(C2=NNN=N2)=C1S(N)(=O)=O)C3=CC=CC4=C3N=C(S4)N)=O

• Molecular Weight:

  480.54

• References & Citations:

  [1]Frank Bennett, et al. Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues. Bioorg Med Chem Lett. 2024 Oct 11:114:129989.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2058069-25-1