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CSC-6

CAT: 0804-HY-161072Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161072Size:1 Each
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Description
CSC-6 is a NLRP3 inhibitor. CSC-6 can significantly inhibit IL-1β secreted by PMATHP-1 cells with an IC50 value of 2.3 μM. CSC-6 specifically binds NLRP3 and inhibits NLRP3 activation by blocking ASC oligomerization during NLRP3 assembly. CSC-6 effectively reduces the symptoms of NLRP3 overactivation-mediated sepsis and gout in mouse models[1].
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/csc-6.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(N2C(S/C(C2=O)=C/C3=C(C(F)(F)F)C=CC=C3)=S)C=C1
Molecular Formula
C18H12F3NO2S2
Molecular Weight
395.42
References & Citations
[1]Shi C, et al. Discovery of NLRP3 inhibitors using machine learning: Identification of a hit compound to treat NLRP3 activation-driven diseases. Eur J Med Chem. 2023 Nov 15;260:115784.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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