EGFR/CSC-IN-1

EGFR/CSC-IN-1

• CAS Number: 2820447-02-5
• UNSPSC Description: EGFR/CSC-IN-1 is a potential EGFR (IC50 10.52 nM) and cancer stem cell (CSC) dual inhibitor for triple-negative breast cancer research.
• Target Antigen: EGFR
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/egfr-csc-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CS(CCN(CC1=CC=C(C2=CC3=C(N=CN=C3NC4=CC=C(OCC5=CC(F)=CC=C5)C(Cl)=C4)C=C2)O1)C(CCC(OCCN6CCN(CC6)CCCN7C8=C(SC9=C7C=C(C=C9)Cl)C=CC=C8)=O)=O)(=O)=O
• Molecular Weight: 1067.08
• References & Citations: [1]Wang Y, et al. Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer. J Med Chem. 2021 Sep 9;64(17):12877-12892.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported