EP300/CBP-IN-1

• UNSPSC Description:

  EP300/CBP-IN-1 (compound 172) is a potent EP300/CBP inhibitor with IC50s of 2.3 nM and 2.1 nM for CBP BRD and EP300 BRD, respectively. EP300/CBP-IN-1 has the inhibitory effect on the proliferation of prostate cancer CWR22RV1 cells[1].

• Target Antigen:

  Epigenetic Reader Domain; Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ep300-cbp-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C2=CC(F)=C(C=C2)Cl)[C@@H](CCO1)C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@@H](CC6)OCC

• Molecular Weight:

  567.05

• References & Citations:

  [1]Lei Fan, et al. An EP300/CBP inhibitor. CN112574189A.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2638507-71-6