EP300/CBP ligand 2

• UNSPSC Description:

  EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958)[1].

• Target Antigen:

  Epigenetic Reader Domain; Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ep300-cbp-ligand-2.html

• Smiles:

  NC1=CC(C2=NN(C)C=C2)=CC(C(NC3=CC=CC4=C3C=C(C)N=N4)=O)=C1

• Molecular Weight:

  358.40

• References & Citations:

  [1]Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported