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PDM-042

CAT: 0804-HY-160111Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-160111Size:1 Each
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Description
PDM-042 is a potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. PDM-042 shows potent inhibitory activities for human and rat PDE10A with IC50 values of less than 1 nM and more than 1000-fold selectivity against other phosphodiesterases. PDM-042 can be used for the research of schizophrenia[1].
CAS Number
[1404488-48-7]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pdm-042.html
Solubility
10 mM in DMSO
Smiles
CC1=NC=C(C)N2C1=NC(/C=C/C3=NC(N4CCCC4)=CC(N5CCOCC5)=N3)=N2
Molecular Formula
C21H26N8O
Molecular Weight
406.48
References & Citations
[1]Arakawa K, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM-042 [ (E) -4- (2- (2- (5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl) vinyl) -6- (pyrrolidin-1-yl) pyrimidin-4-yl) morpholine] in rats: potential for the treatment of schizophrenia. Pharmacol Res Perspect. 2016 Jun 10;4 (4) :e00241.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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