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ISM012-042

CAT: 0931-T204762-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204762-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Chromatin/Epigenetic, Metabolism
Bioactivity
ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.
Smiles
CC(C)(C)OC(=O)N1CCN(CC1)C2=NC3=CN=C(C(=C3C=C2)O)C(=O)NCC4=CC=C(C=C4)C#N
Molecular Formula
C26H28N6O4
Molecular Weight
488.538
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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